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2 g/dayOral: 20 mg/kg every 12 hoursMaximum dose: 2 g/dayUsual Pediatric Dose for Plague:Use of plague as a biological weapon:Treatment, contained-casualty setting: 15 mg/kg IV twice daily for 10 days (maximum 1 g/day); may switch to oral ciprofloxacin when clinically indicatedThe Working Group on Civilian Biodefense has recommended ciprofloxacin as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro. Among the gram-positive bacteria, in vitro sensitivity has been shown for Staphylococcus species (including penicillin and methicillin resistant strains) and betahemolytic streptococci which are sensitive to gentamicin. Specifically, gentamicin is active against the following organisms commonly isolated from canine ears: Staphylococcus aureus, other Staphylococcus spp. In the event of overdose or toxic reactions, hemodialysis may aid in the removal of gentamicin from the blood, especially if renal function is, or becomes, compromised. Gentamicin crosses the peritoneal as well as the placental membrane.

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